医学部保健学科

検査技術学専攻

助教:堀江 香代

kayo horie
学位
博士(医学)
職位
助教
所属
保健学研究科 医療生命科学領域 病態解析科学分野
電話番号
0172-39-5972
e-mail
k-horie
※アカウントの後に「@hirosaki-u.ac.jp」を加えてください。

学部

専攻

検査技術科学専攻

研究テーマ

・網羅的Micro RNA解析を用いたヒト卵巣癌プロファイルの探索
・卵巣癌の増殖・浸潤を抑制するエクソソーム内在マイクロRNA探索と作用機序の解明
・プロゲステロンによる子宮内膜癌・増殖抑制刺激伝達系の網羅的解析

前期課程

研究領域

生体検査科学領域

研究テーマ

・網羅的Micro RNA解析を用いたヒト卵巣癌プロファイルの探索
・卵巣癌の増殖・浸潤を抑制するエクソソーム内在マイクロRNA探索と作用機序の解明
・プロゲステロンによる子宮内膜癌・増殖抑制刺激伝達系の網羅的解析

キーワード

病理組織細胞学
卵巣癌エクソソーム
microRNA
子宮内膜癌のエストロゲン・プロゲステロン作用

業績

著書

学術論文

 1. Horie K, Mikami T,Yoshida T,Sato Y ,Okayasu I .Peroxiredoxin 1 expression in active ulcerative colitis mucosa identified by proteome analysis and involvement of thioredoxin based on immunohistochemistry. Oncol Lett, (in press), 2017.

2. Nanashima N, Horie K, Chiba M, Nakano M, Maeda H, Nakamura T. Anthocyanin‑rich blackcurrant extract inhibits proliferation of the MCF10A healthy human breast epithelial cell line through induction of G0/G1 arrest and apoptosis. Mol Med Rep 16:  6134-6141,  2017.

3. Nanashima N, Horie K, Yamada T, Shimizu T, Tsuchida S. Hair keratin KRT81 is expressed in normal and breast cancer cells and contributes to their invasiveness. Oncol Rep, 37(5), 2964-2970, 2017.

4.
堀江 香代, 後藤 勇也, 野呂 美鈴, 吉岡 治彦, 刀稱 亀代志, 小島 啓子, 横山 良仁,渡邉 純. 子宮内膜液状化検体細胞診法(LBC法)の精度向上を目的とした細胞像と画像解析の比較. 医学検査 Vol. 66 No. 2  p.96-102, 2017

5. Mizunuma M, Yokoyama Y, Futagami M, Horie K, Watanabe J, Mizunuma H. FOXP1 forkhead transcription factor is associated with the pathogenesis of endometrial cancer. Heliyon. (5):e00116, 2016.

 
6. Nanashima N, Horie K, Tomisawa T, Chiba M, Nakano M, Fujita T, Maeda H, Kitajima M, Takamagi S, Uchiyama D, Watanabe J, Nakamura T, Kato Y. Phytoestrogenic activity of blackcurrant (Ribes nigrum) anthocyanins is mediated through estrogen receptor alpha. Molecular Nutrition Food Research, 59(12):2419-31, 2015

 7. Yoshioka, H., Kondo, H., Horie, K., Washiya, k.,Watanabe, J. Evaluation of Endometrial Endometrioid Carcinoma Grade using Ultraviolet-Visible Light Microscopic Spectroscopy. J Cytol Histol. 6(6):381, 2015.

 8. Yoshioka, H., Hoshiai, K., Nakamura, T., Horie, K., Washiya, k.,Watanabe, J. Usefulness of Evaluation of Nuclear Color by Visible-Microscopic Spectroscopy for Objective Differentiation between Non-Cancer and Cancer Cells Prepared Using Liquid-Based Cytology. J Cytol Histol. 6(1):308, 2015.

 9. Fujitani Nª, FurukawaJª, Araki(Horie) Kª, Fujioka T, Takegawa Y, Piao J, Nishioka T, Tamura T, Nikaido T, Ito M, Nakamura Y, Shinohara Y  (a: equally contrubuted) Total cellular glycomics allows characterizing cells and streamlining the discovery process for cellular biomarkers.PNAS, 110: 2105-2110, 2013.

10. Takegawa Y, Araki(Horie) K, Fujitani N, Furukawa J, Sugiyama H, Sakai H, Shinohara Y Simultaneous analysis of heparan sulfate, chondroitin/dermatan sulfates and hyaluronan disaccharides by glycoblotting-assisted sample preparation followed by single-step ZIC-HILIC chromatography.  Anal Chem, 83:9443-9449, 2011.

 11. Furukawa J, Fujitani N, Araki(Horie) K, Kodama K, Shinohara Y.  A versatile method for the analysis of serine/threonine post-translational modifications by beta-elimination in the presence of pyrazolone analogues.Anal Chem, 83:9060-9067, 2011.

 12. Fujitani N, Takegawa Y, Ishibashi Y, Araki(Horie) K, Furukawa J, Mitsutake S, Igarashi Y, Ito  M, Shinohara Y. Qualitative and Quantitative CellularGlycomics of Glycosphingolipids Based on Rhodococcal EGCase -Assisted Glycan Cleavage, Glycoblotting-Assisted Sample Preparation and MALDI-TOF/TOFMS Analysis.  J Biol Chem.  286:41669-41679, 2011.

13. Araki(Horie) K, Mikami T, Yoshida T, Kikuchi M, Sato Y, Oh-ishi M, Kodera Y, Maeda T, Okayasu I. High expression of HSP47 in ulcerative colitis-associated carcinomas: proteomic approach.Br J Cancer, 101:492-497, 2009.

14. Okayasu I, Yoshida T, Mikami T, Hana K, Yokozawa M,  Araki(Horie)  K , Mitsuhashi J, Kikuchi M, Adachi.  Mucosal remodeling in long-standing ulcerative colitis with colorectal neoplasia: significant alterations of NCAM+ or alpha-SMA+ subepithelial myofibroblasts and interstitial cells. Pathology International, 59:701-711, 2009.

15. Kikuchi M, Mikami T, Sato T, Tokuyama W, Araki(Horie) K, Watanabe M,  Saigenji K, Okayasu I. High Ki67, Bax, and thymidylate synthase expression well correlates with response to chemoradiation therapy in locally advanced rectal cancers: proposal of a logistic model for prediction. Br J Cancer, 101:116-123, 2009

16. Umeto H, Yoshida T, Araki(Horie) K, Yagishita H, Mikami T, Okayasu I.  Appearance of epithelial and stromalgenomic instability in background colorectal mucosa of sporadic colorectal cancer patients: relation  to age and gender.Journal of Gastroenterology, 44: 1036-1045, 2009.

17. Mikami T, Yoshida T, Numata Y, Shiraishi H, Araki(Horie) K, Guiot MC, Jass JR, Okayasu I Low frequency of promoter methylation of O⁶-methylguanine DNA methyltransferase and hMLH1 in ulcerative colitis-associated tumors: comparison with sporadic colonic tumors.  American Journal of Clinical Pathology 127:366-37, 2007.

 18. Sato S, Kijima H, Suto A, Yoshida H, Sato T, Shimbori M, Terasaki-Fukazawa Y, Onoda N, Araki(Horie) K, Tsuruno K, Takeshita. Fine-needle aspiration cytology of breast lesions: a review of cytological analysis using smooth muscle actin (SMA) immunostaining.. Anticancer Research 23: 4175-4180, 2003.

 

 



 

 

総説/解説

社会活動

所属学会

日本臨床細胞学会
日本臨床衛生検査技師会
日本癌学会
The international academy of cytology

備考

リンク
弘前大学HP 教育研究総覧 弘前大学医学部保健学科検査技術科学専攻細胞検査士養成課程HP
研究内容
平成26年度弘前大学若手支援事業成果発表ポスター 平成27年度弘前大学若手支援事業成果発表ポスター
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