弘前大学医学部保健学科・大学院保健学研究科

■ 教授：山田　順子

学位

博士（学術）

職位

教授

所属

医療生命科学領域　生体機能科学分野　

電話番号

0172-39-5985

e-mail

jyamada
※アカウントの後に「@hirosaki-u.ac.jp」を加えてください。

学部

■ 専攻

作業療法学専攻

■ 研究テーマ

脳神経生理学的手法を中心にこころのしくみ、病態解析、治療法の開発などの研究を行っています。

前期課程

■ 研究領域

総合リハビリテーション科学領域

■ 研究テーマ

○脳の性差とこころの性差に関する神経生理学的解析
○モデル動物を用いたリハビリテーションと脳の可塑性の研究
○中枢神経系のGABA抑制機構を中心とした神経回路機能の研究
○放射線照射による脳機能への影響に関する研究

後期課程

■ 研究領域

総合リハビリテーション科学領域

■ 研究テーマ

○神経疾患モデルマウスを用いた病態解析及び新規治療法の開発
○新規リハビリテーション法開発へむけた神経可塑性の研究
○生理学的手法を用いた脳の発達・再生・可塑性・病態メカニズムの研究
○放射線照射による脳機能への影響に関する研究
○脳の性差，こころの性差に関する研究

■ キーワード

発達、精神疾患、神経疾患、てんかん、GABA、脳内の抑制性機構

業績

■ 著書

■ 学術論文

1.      Furukawa T.,Yamada, J., Akita T., Matsushima Y., Yanagawa Y.,Fukuda A. Roles of taurine-mediated tonic GABAA receptor activation in the radial migration of neurons in the fetal mouse cerebral cortex. Fonriers in Cellular Neurosci. 2014 doi: 10.3389/fncel.2014.00088. eCollection 2014.

2.        Tomonoh Y, Deshimaru M, Araki, Miyazaki Y, Arasaki T, Tanaka Y, Kitamura H, Mori F, Wakabayashi K, YamashitaS, Saito R, Itoh M, UchidaT, YamadaJ, Migita K, Ueno S, Kitaura H, Kakita A, Lossin C, Takano Y, Hirose S. The Kick-In System: A Novel Rapid Knock-In Strategy Plos One One. 2014 Feb 19;9(2):e88549. doi: 10.1371/journal.pone.0088549. eCollection 2014

3.        Ueno T, Yamada J, Nishijima H, Arai A, Migita K, Baba M, Ueno s, Tomiyama M. Morphological and electrophysiological changes in intratelencephalic-type pyramidal neurons in the motorcortex of a rat model of levodopa-induced dyskinesia. Neurobiology of Disease . 2014 Apr;64:142-9. doi: 10.1016/j.nbd.2013.12.014. Epub 2014 Jan 4

4.        Nishijima H, Suzuki S, Kon T, Funamizu Y, Ueno T, Haga R, Miki Y, Suzuki C, Arai A, Kimura T, Suzuki C, Meguro R, Yamada J, Migita K, Ichinohe N, Ueno S, Baba M, Tomiyama M. Morphologic changes of dendritic spines of striatal projection neurons in a rat model of L-DOPA-induced dyskinesia. Movement Disorders 2014 Mar;29(3):336-43.doi: 10.1002/mds.25826.

5.        Yamada J., Zhu G., Okada M., Hirose S., Yoshida S., Shiba Y., Migita K., Mori F., Sugawara T., Chen L., LiuF., Yoshida S., Ueno S., Kaneko S. (2013) A novel prophylactic effect of furosemide treatment on autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) Epi. Res. 107 (1-2):127-37 doi: 10.1016/j.eplepsyres.2013.08.018. Epub 2013 Sep 3.

6.        Egawa K., Yamada J., Furukawa T., Yanagawa Y., Fukuda A. (2013)  Cl^- homeodynamics in gap-junction-coupled astrocytic networks on activation of GABAergic synapses. J. Physiol. Aug 15; 591: 3901-3917doi: 10.1113/jphysiol.2013.257162. Epub 2013 Jun 3.

7.        Migita K, Yamada J, Nikaido Y, Shi X, Kaneko S, Hirose S, Ueno S. (2013) Properties of a Novel GABA(A) Receptor γ(2) Subunit Mutation Associated With Seizures. J. Pharmacol. Sci. 121(1):84-7

8.        Nishijima H, Arai A, Kimura T, Mori F, Yamada J, Migita K, Wakabayashi K, Baba M, Ueno S, Tomiyama M. (2013) Drebrin immunoreactivity in the striatum of a rat model of levodopa-induced dyskinesia. Neuropathology 33: 391-396

9.        Inoue, K., Furukawa, T., Kumada, T., Yamada J., Wang, TY., Inoue, R.,Fukuda, A. (2012) Taurine Inhibits K+-Cl- Cotransporter KCC2 to Regulate Embryonic Cl- Homeostasis via With-no-lysine (WNK) Protein Kinase Signaling Pathway. J. Biol Chem. 287 (25):20839-20850

10.    Zhu G., Yoshida S., Migita K., Yamada J., Mori F., Tomiyama M., Wakabayashi K., Kanematsu T., Hirata M., Kaneko S., Ueno S and Okada M. (2012) Dysfunction of extrasynaptic GABAergic transmission in PRIP-1 KO mice is associated with an epilepsy phenotype. J Pharmacol Exp Ther.  340 (3):520-8

11.    Migita K., Tomiyama M., Yamada J., Fukuzawa M., Kanematsu T., Hirata M., Ueno S (2011) Phenotypes of pain behavior in phospholipase C-related but catalytically inactive protein type 1 knockout mice. Molecular pain 7:79

12.    Yamada J., Inoue K., Furukawa T., Fukuda A. (2010) A  low-concentration  tributyltin deteriorates  inhibitory  synaptogenesis  and  induces neuronal death in immature but not mature neurons Toxicol. Lett. 198 (2):282-288.

13.    Migita K., Honda K., Yamada J., Takano Y., Ueno S. (2010) Involvement of P2X₂ and P2X₃ receptors in dorsal root ganglion neurons of streptozotocin-induced diabetic neuropathy. Hirosaki Med J. 61(Suppl.): S255-S261.

14.    Sipilä S., Huttu K., Yamada J., Afzalov R., Voipio J., Blaesse P., and Kaila K. (2009) compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J. Neurosci. 29 (21):6982-8.

15.    Khirug S., Yamada J.　(contributed equally with K.S.), Afzalov R., Voipio J., Khiroug L., Kaila K. (2008) GABAergic depolarization of the axon initial segment in cortical principal neurons is caused by the Na-K-2Cl cotransporter NKCC1. J. Neurosci. 28 (18):4635-39.

16.    Achilles,K., Okabe, A.,  Ikeda, M., Shimitzu-Okabe, C. Yamada, J., Fukuda, A., Luhmann, H.J. and Kilb, W (2007)  Kinetic properties of Cl^- uptake mediated by Na⁺-dependent K⁺-2Cl^--cotransport in immature rat neocortical neurons. J. Neurosci. 27(32):8616-27.

17.    Yamada,J., Furukawa T., Ueno, S.,  Yamamoto, S., and Fukuda, A. (2007) Molecular basis for the GABA_A receptor-mediated tonic inhibition in rat somatosensory cortex Cerebral cortex 17(8):1782-7.

18.    Nakanishi, K., Yamada, J., Takayama, C., Oohira, A. and Fukuda, A. (2007) NKCC1 activity modulates formation of functional inhibitory synapses in cultured neocortical neurons. (2007) Synapse Mar;61(3):138-49.

19.    Yamamoto, S., Yamada,J., Ueno, S., Kubota, H., Yamamoto, S. and Fukuda, A.(2007) Insertion of a7 Nicotinic Receptors at Neocortical Layer V GABAergic Synapses is Induced by a Benzodiazepine, Midazolam. Cerebral cortex  Mar.17(3): 653-60.

20.    Sipilä, S., Schuchmann, S., Voipio, J., Yamada, J. and Kaila, K. (2006) The Na-K-Cl cotransporter (NKCC1) Promotes Sharp Waves in the Neonatal Rat Hippocampus. J.Physiol. 573: 765-73

21.    Inoue, K., Yamada, J., Ueno, S., Fukuda, A. (2006) Brain-type creatine kinase activates neuron-specific K-Cl co-transporter KCC2. J. Neurochem. 96(2):598-608.

22.    Inoue, K., Ueno, S., Yamada, J., Fukuda, A. (2005) Characterization of newly cloned variant of rat glycine. BBRC. 4:327(1): 300-5.

23.    Toyoda, H., Yamada, J., Ueno, S., Okabe A., Kato, H.,Sato K.,Hashimoto, K and Fukuda, A. (2005) Differential functional expression of cation-Cl- cotransporter mRNAs (KCC1, KCC2,and NKCC1) in rat trigeminal nervous system. Molecular Brain Res.5:133(1):12-8.

24.    Ueta, Y., Fujihara, H., Serino, R., Dayanithi, G., Ozawa, H., Matsuda, K., Kawata, M., Yamada, J., Ueno, S., Fukuda, A., Murphy, D.(2005) Transgenic Expression Enhanced Green Fluorescent Protein Enables Direct Visualization for Physiological Studies of Vasopressin Neurons and Isolated Nerve Terminals of the Rat. Endocrinology. 146 (1): 406-13.

25.    Ikeda, K., Onimaru, H., Yamada,J., Inoue, K., Ueno, S., Onaka, T., Toyoda, H., Arata, A., Ishikawa, T., Taketo, M., Fukuda, A., and Kawakami, K. (2004) Malfunction of respiratory related neuronal activity in Na⁺, K⁺-ATPase a2 subunit-deficient mice is due to abnormal Cl^- homeostasis in brainstem neurons. J. Neurosci. 24 (47):10693-701.

26.    Yamada, J., Okabe., A.,Toyoda, H., Kilb, W., Luhmann, H. and Fukuda, A. (2004) Cl^- uptake promoting depolarizing GABA actions in immature rat neocortical neurones is mediated by NKCC1. J.Pysiol. 557:829-41.

27.    Isomura Y, Sugimoto M, Fujiwara-Tsukamoto Y, Yamamoto-Muraki S, Yamada J, and Fukuda A. (2003)  Synaptically activated Cl^- accumulation responsible for depolarizing GABAergic responses in mature hippocampal neurons. J.Neurophysiol. 90: 2752-6.

28.    Ikeda M, Toyoda H, Yamada J., Okabe A, Sato K, Hotta Y, Fukuda A. (2003)  Differential development of cation-chloride cotransporters and Cl^- homeostasis contributes to differential GABAergic actions between developing rat visual cortex and dorsal lateral geniculate nucleus. Brain Res. 12: 149-59

29.    Toyoda,H., Ohno, K., Yamada, J., Ikeda, M., Okabe,A., Sato,K.,Hashimoto,K., Fukuda,A. (2003)  Induction of NMDA and GABA_A receptors-mediated Ca²⁺ oscillations with KCC2 mRNA downregulation in injured facial motoneurons.  J. Neurophysiol. 89:1353-1362

30.    Konishi, S., Saitow, F., Satake, S., Yamada, J., Ikebuchi, Y. and Suzuki, H. (2001)Molecular mechanism underlying facilitation of cerebellar GABA-mediated transmission following activation of monoaminergic afferent fibers. Biogenic Amines 16:115-125

31.    Saitow, F., Satake, S., Yamada, J., and Konishi, S. (2000)  b■ 総説/解説

Konishi, S., Yamada, J., Satake, S, and Saitow, F. (1998)  Ionotropic and  metabotropicreceptors. Clinicl Neuroscience (Cyugai Igakusha), 16, 1010-1015 (in Japanese)

 右田啓介、山田順子、上野伸哉“痛み”

月刊臨床神経科学・中外医学社　(2011) 29, 836-838

■ 社会活動

‐

■ 所属学会

日本生理学会（評議員）
日本脳科学会（評議員）
日本神経科学会
北米神経科学会
日本女性生理学者の会

■ 備考

‐

■ リンク

旧所属先

大学院保健学研究科

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