大学院保健学研究科

生体機能科学領域

准教授:三浦 富智

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学位
博士(医学)
職位
准教授
所属
大学院保健学研究科
電話番号
0172-39-5966
e-mail
tomisato
※アカウントの後に「@hirosaki-u.ac.jp」を加えてください。

学部

専攻

検査技術科学専攻

研究テーマ

・新規細胞遺伝学的線量評価能の開発
・リンゴプロシアニジンの生活習慣病予防効果の解明
・被ばく影響マーカーの検索
・放射線生物影響調査(復興支援)

前期課程

研究領域

生体検査科学領域

研究テーマ

○新規細胞遺伝学的被ばく線量評価法の開発
○染色体異常に及ぼす背景因子の解析
○プロシアニジン類の腸管ホメオダイナミクスによる生活習慣病予防作用の解明
〇職業被ばくにおける染色体異常の解析
○放射線被ばくの生物影響研究
○抗菌性タンパク質の活性調節機構に関する研究
○ヒアルロン酸合成の調節に関する研究

後期課程

研究領域

生体検査科学領域

研究テーマ

○新規細胞遺伝学的被ばく線量評価法の開発
○染色体異常に及ぼす背景因子の解析
○プロシアニジン類の腸管ホメオダイナミクスによる生活習慣病予防作用の解明
〇職業被ばくにおける染色体異常の解析
○放射線被ばくの生物影響研究
○抗菌性タンパク質の活性調節機構に関する研究
○ヒアルロン酸合成の調節に関する研究

キーワード

緊急被ばく医療 バイオドシメトリー PCC法 リンゴプロシアニジン 放射線影響

業績

著書

Miura T, Mizuki D, Sasaki S, Hasegawa S, Sashinami H, Nakane A.: Excep. Medica Inter. Cong. Series 1216. Progress in transplantation. pp.51-57(2000)

メディカルサイエンス遺伝子検査学「リアルタイムPCR法」近代出版, 105-107.

Shoji T, Miura T. Polyphenols in Human Health and Disease. 1st ed. Apple polyphenols in cancer prevention. Elsevier. 339-351(2013)

学術論文

・S L Sugarman, G K Livingston, D L Stricklin, M G Abbott, R C Wilkins, H Romm, U Oestreicher, M A Yoshida, T Miura, J E Moquet, M Di Giorgio, C Ferrarotto, G A Gross, M E Christiansen, C L Hart, D M Christensen: The Internet's Role in a Biodosimetric Response to a Radiation Mass Casualty Event.. Health physics 05/2014; 106(5 Suppl 2):S65-70.

・Tomisato Miura, Akifumi Nakata, Kosuke Kasai, Manabu Nakano, Yu Abe, Eiki Tsushima, Natalia I Ossetrova, Mitsuaki A Yoshida, William F Blakely: A NOVEL PARAMETER, CELL-CYCLE PROGRESSION INDEX, FOR RADIATION DOSE ABSORBED ESTIMATION IN THE PREMATURE CHROMOSOME CONDENSATION ASSAY.. Radiation Protection Dosimetry 04/2014;

・Tomisato Miura, Akifumi Nakata, Kosuke Kasai, Yu Abe, Yutaka Jin, Mitsuaki A. Yoshida: Healthcare of 18 workers who supported the regulation of radiological contaminations at the Fukushima Daiichi nuclear power plant. Radiation Emergency Medicine. 08/2013; 2(2):63-67.

・Hiroyuki Nozaka, Tomisato Miura, Zhongxi Zheng: Multi-layer virtual slide scanning system with multi-focus image fusion for cytopathology andiImage diagnosis. IEICE Transactions on Information and Systems 04/2013; E96-D(4):856-863.

・Kimihiko Satoh, Daishi Yamakawa, Kosuke Kasai, Makoto Hayakari, Koji Uchida, Tomisato Miura: Nonclonal growth of preneoplastic cells positive for glutathione S-transferase P-form in the rat liver.. Cancer Science 05/2012; 103(8):1445-50.

・Tomisato Miura, Akifumi Nakata, Kosuke Kasa, Mitsuaki Yoshida: Effects of colcemid-block on chromosome condensation in metaphase analysis and premature chromosome condensation assays. Radiation Emergency Medicine. 03/2012; 1(1-2):70-74.

・Mitsuru Chiba, Tomisato Miura, Kosuke Kasai, Satoru Monzen, Ikuo Kashiwakura, Hiroshi Yasue, Toshiya Nakamura: Identification of up-regulated and down-regulated cis-natural antisense transcripts in the human B lymphoblastic cell line IM-9 after X-ray irradiation.. Molecular Medicine Reports 02/2012; 5(5):1151-7.

・Tomisato Miura, William F Blakely: Optimization of calyculin A-induced premature chromosome condensation assay for chromosome aberration studies.. Cytometry Part A 11/2011; 79(12):1016-22.

・Kiyotada Washiya, Tatsusuke Sato, Tomisato Miura, Kiyosi Tone, Keiko Kojima, Jun Watanabe, Hiroshi Kijima: Cytologic difference between benignity and malignancy in suspicious cases employing urine cytodiagnosis using a liquid-based method.. Analytical and quantitative cytology and histology / the International Academy of Cytology [and] American Society of Cytology 06/2011; 33(3):169-74.

・Zhongxi Zheng, Tomisato Miura, Hiroyuki Nozaka, Terumasa Takamatsu, Tatsusuke Sato: AN AUTOMATED FOCUS FUSION ALGORITHM FOR INFORMATIVE CYTOLOGICAL IMAGE. Hirosaki Medical Journal 01/2011;

・Miho Honma, Shinji Kudo, Noboru Takada, Kazuaki Tanaka, Tomisato Miura, Masaru Hashimoto: ChemInform Abstract: Novel Neofusapyrones Isolated from Verticillium dahliae as Potent Antifungal Substances. ChemInform 01/2010; 41(24).

・Miho Honma, Shinji Kudo, Noboru Takada, Kazuaki Tanaka, Tomisato Miura, Masaru Hashimoto: Novel neofusapyrones isolated from Verticillium dahliae as potent antifungal substances.. Bioorganic & medicinal chemistry letters 12/2009; 20(2):709-12.

・Kosuke Kasai, Takashi Ishikawa, Takafumi Komata, Kaori Fukuchi, Mitsuru Chiba, Hiroyuki Nozaka, Toshiya Nakamura, Tatsusuke Sato, Tomisato Miura: Novel L-amino acid oxidase with antibacterial activity against methicillin-resistant Staphylococcus aureus isolated from epidermal mucus of the flounder Platichthys stellatus.. FEBS Journal 12/2009; 277(2):453-65.

・Miyuki Fujioka, Kosuke Kasai, Tomisato Miura, Tatsusuke Sato, Yoshimitsu Otomo: Rapid diagnostic method for the detection of diarrheagenic Escherichia coli by multiplex PCR.. Japanese journal of infectious diseases. 11/2009; 62(6):476-80.

・Rie Terasawa, Yukako Fukushi, Satoru Monzen, Tomisato Miura, Kenji Takahashi, Atsushi Yoshizawa, Ikuo Kashiwakura: The promoting activity on human megakaryocytopoiesis and thrombopoiesis by liquid crystal-related compounds.. Biological & Pharmaceutical Bulletin 07/2009; 32(6):976-81.

・Mihoko Sutoh, Mitsuru Chiba, Kosuke Kasai, Tomisato Miura, Hiroyuki Nozaka, Kiyotada Washiya, Etsuko Okusawa, Naoto Oyama, Chikako Tsutaya, Megumi Tsushima, Yuriko Terayama, Tomihisa Funyu, Tatsusuke Sato: Hepatoid carcinoma of the skin: spontaneous rat skin hepatoid carcinoma with eosinophilic globules and crystals immunoreactive to alpha-1-antitrypsin.. Medical Molecular Morphology 07/2009; 42(2):118-22.

・Takanori Murakami, Taro Tsushima, Noboru Takada, Kazuaki Tanaka, Ken-ichi Nihei, Tomisato Miura, Masaru Hashimoto: Four analogues of spiroleptosphol isolated from Leptosphaeria doliolum.. Bioorganic & medicinal chemistry 01/2009; 17(2):492-5.

・Tomisato Miura, Mitsuru Chiba, Kosuke Kasai, Hiroyuki Nozaka, Toshiya Nakamura, Toshihiko Shoji, Tomomasa Kanda, Yasuyuki Ohtake, Tatsusuke Sato: Apple procyanidins induce tumor cell apoptosis through mitochondrial pathway activation of caspase-3.. Carcinogenesis 04/2008; 29(3):585-93.

・M Chiba, M Kubo, T Miura, T Sato, A H Rezaeian, H Kiyosawa, N Ohkohchi, H Yasue: Localization of sense and antisense transcripts of Prdx2 gene in mouse tissues.. Cytogenetic and Genome Research 02/2008; 121(3-4):222-31.

・Rika Nakamura, Hiroko Kuwabara, Masahiko Yoneda, Shuichi Yoshihara, Takashi Ishikawa, Tomisato Miura, Hiroyuki Nozaka, Naoki Nanashima, Tatsusuke Sato, Toshiya Nakamura: Suppression of matrix metalloproteinase-9 by 4-methylumbelliferone.. Cell Biology International 10/2007; 31(9):1022-6.

・Tatsusuke Sato, Tomisato Miura, Hiroyuki Nozaka, Yosei Katayama, Akira Moriuchi, Shinichi Nakamura, Zhongxi Zheng, Terumasa Takamatsu: [Progression in diagnostic pathology; development of virtual microscopy and its applications].. Rinsho byori. The Japanese journal of clinical pathology 05/2007; 55(4):344-50.

・Kimihiko Satoh, Gen Takahashi, Tomisato Miura, Makoto Hayakari, Ichiro Hatayama: Enzymatic detection of precursor cell populations of preneoplastic foci positive for gamma-glutamyltranspeptidase in rat liver.. International Journal of Cancer 08/2005; 115(5):711-6.

・Suguru Hasegawa, Shinsuke Nishikawa, Tomisato Miura, Yoshihiko Saito, Hiroo Madarame, Kenji Sekikawa, Yoh-Ichi Tagawa, Yoichiro Iwakura, Akio Nakane: Tumor necrosis factor-alpha is required for gastritis induced by Helicobacter felis infection in mice.. Microbial Pathogenesis 10/2004; 37(3):119-24.

・Toshiya Nakamura, Takashi Ishikawa, Naoki Nanashima, Tomisato Miura, Hiroyuki Nozaka, Rie Nakaoka, Tatsusuke Sato: 4-Methylumbelliferone induces the expression of membrane type 1-matrix metalloproteinase in cultured human skin fibroblasts.. Biochemical and Biophysical Research Communications 12/2002; 298(5):646-50.

・Takashi Ohata, Yoshinao Abe, Tomisato Miura, Tatsusuke Sato: [An experimental study for tumor detection by indocyanine green with near-infrared topography].. Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica 06/2002; 62(6):284-6.

・Suguru Hasegawa, Tomisato Miura, Sanae Sasaki, Hiroo Madarame, Akio Nakane: Dysregulation of interleukin-10 and interleukin-12 are involved in the reduced host resistance to Listeria monocytogenes infection in alymphoplastic aly mutant mice.. FEMS Immunology & Medical Microbiology 02/2002; 32(2):111-7.

・T Miura, T Kudo, A Matsuki, K Sekikawa, Y Tagawa, Y Iwakura, A Nakane: Effect of 6-hydroxydopamine on host resistance against Listeria monocytogenes infection.. Infection and Immunity 01/2002; 69(12):7234-41.

・D Mizuki, T Miura, S Sasaki, M Mizuki, H Madarame, A Nakane: Interference between host resistance to Listeria monocytogenes infection and ovalbumin-induced allergic responses in mice.. Infection and Immunity 04/2001; 69(3):1883-8.

・T Miura, D Mizuki, S Sasaki, S Hasegawa, H Sashinami, A Nakane: Host resistance to Listeria monocytogenes infection is enhanced but resistance to Staphylococcus aureus infection is reduced in acute graft-versus-host disease in mice.. Infection and Immunity 08/2000; 68(7):4340-3.

・Tomisato Miura, Shinsuke Nishikawa, Sanae Sasaki, Kyogo Yamada, Suguru Hasegawa, Daisuke Mizuki, Mayuko Mizuki, Ichiro Hatayama, Kenji Sekikawa, Yoh-ichi Tagawa, Yoichiro Iwakura, Akio Nakane: Roles of endogenous cytokines in liver apoptosis of mice in lethal Listeria monocytogenes infection. FEMS Immunology & Medical Microbiology 07/2000; 28(4):335 - 341.

・Sanae Sasaki, Shinsuke Nishikawa, Tomisato Miura, Mayuko Mizuki, Kyogo Yamada, Hiroo Madarame, Yoh-Ichi Tagawa, Yoichiro Iwakura, Akio Nakane: Interleukin-4 and Interleukin-10 Are Involved in Host Resistance to Staphylococcus aureus Infection through Regulation of Gamma Interferon. Infection and Immunity 01/2000;

・Akio Nakane, Kyogo Yamada, Suguru Hasegawa, Daisuke Mizuki, Mayuko Mizuki, Sanae Sasaki, Tomisato Miura: Erratum to: “Endogenous cytokines during a lethal infection with Listeria monocytogenes in mice”: [FEMS Microbiology Letters 175 (1999) 133–142]1. FEMS Immunology & Medical Microbiology 09/1999; 25(4):403.

・S Sasaki, T Miura, S Nishikawa, K Yamada, M Hirasue, A Nakane: Protective role of nitric oxide in Staphylococcus aureus infection in mice.. Infection and Immunity 04/1998; 66(3):1017-22.

・A Nakane, M Asano, T Miura, S Sasaki, S Nishikawa, M Kohanawa, T Minagawa: Neuropeptides in the livers of mice during bacterial infections.. FEMS Immunology & Medical Microbiology 02/1998; 20(2):159-64.

・S Nishikawa, M Hirasue, T Miura, K Yamada, S Sasaki, A Nakane: Systemic dissemination by intrarectal infection with Listeria monocytogenes in mice.. Microbiology and Immunology 02/1998; 42(4):325-7.

・S Nishikawa, T Miura, S Sasaki, A Nakane: The protective role of endogenous cytokines in host resistance against an intragastric infection with Listeria monocytogenes in mice.. FEMS Immunology & Medical Microbiology 01/1997; 16(3-4):291-8.

・A Nakane, M Asano, S Sasaki, S Nishikawa, T Miura, M Kohanawa, T Minagawa: Transforming growth factor beta is protective in host resistance against Listeria monocytogenes infection in mice.. Infection and Immunity 10/1996; 64(9):3901-4.

・A Nakane, S Nishikawa, S Sasaki, T Miura, M Asano, M Kohanawa, K Ishiwata, T Minagawa: Endogenous interleukin-4, but not interleukin-10, is involved in suppression of host resistance against Listeria monocytogenes infection in interferon-depleted mice.. Infection and Immunity 05/1996; 64(4):1252-8.

・A Nakane, S Nishikawa, S Sasaki, T Miura, M Asano, M Kohanawa, T Minagawa: A monoclonal antibody against T-cell receptor alpha beta induces endogenous cytokines and prevents mice from a lethal infection with Listeria monocytogenes.. FEMS Immunology & Medical Microbiology 08/1995; 11(4):321-7.

総説/解説

社会活動

・浪江町復興支援
・革新的技術開発・緊急展開事業(対象者 果樹(リンゴ))事業成果報告
(内容については下記リンクの「革新的技術開発・緊急展開事業(対象者 果樹(リンゴ))事業成果報告」からご覧ください)

所属学会

日本放射線影響学会

備考

リンク
弘前大学HP [弘前大学 教育研究総覧] 弘前大学大学院保健学研究科分子細胞生物学研究室 革新的技術開発・緊急展開事業(対象者 果樹(リンゴ))事業成果報告
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